Frances Creighton resorts to poisoning her relatives with arsenic when they no longer become of use to her. After being acquitted of murdering her own brother, Frances moves to New York and begins an affair with a married man. Her lover's wife is a gossip who threatens to tell the neighbors about Frances' dark past, and Frances decides to silence her permanently.
Meanwhile, Betty Neumar had five husbands - four of whom died suspiciously while married to Betty. For decades, no one connects any of the deaths until a cold case investigation reveals Betty's murderous deeds.
And 72-year-old Millicent Cumberbatch and her husband Stanley were married for 38 years, but their union wasn't always a happy one. After a formal separation and her husband's year-long affair, a scorned and heartbroken Millicent decides to end their marriage, permanently.