Theresa Riggi's lack of trust in others leads her to isolate her children from society and have complete control over them. Furious at this, her husband gets four-hour visitations every week upon divorcing her and when he tries to apply for full custody, she stabs all three children and makes an unsuccessful attempt to commit suicide.
Meanwhile, Elise Ledvina is known in Milwaukee as a caring Catholic mother who values setting a good example, but secretly battles with intense delusions due to schizophrenia. Convinced she's a bad mother and that this world was a bad place for her two sons, the voices in her head drive her to bludgeon them with a baseball bat; her elder son is saved due to his father's intervention, but the younger son dies. She is acquitted by reason of insanity.
And young Philadelphia housewife Marie Noe never really wanted children, unlike her devoted husband Arthur, and is unable to emotionally cope with the stresses of motherhood. Over two decades, she gives birth to ten children and two of them are stillborn, but none of the surviving children live long as she smothers them when they're alone. She isn't caught until 50 years after the first murder.
- Murder of Innocence is also a 1993 TV film about female school shooter Laurie Dann.